Browsing by Subject "DNA damage"
Now showing items 1-7 of 7
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THE ANTICANCER ACTIVITY AND MECHANISMS OF ACTION OF JADOMYCINS IN MULTIDRUG RESISTANT HUMAN BREAST CANCER CELLS
(2018-09-28)Breast cancer is the most common cancer in women, and approximately one third of all breast cancers will ultimately metastasize. Metastatic breast cancer is classified as an incurable disease. The development of multidrug ... -
CHEMOPREVENTIVE EFFECT OF HASKAP BERRY POLYPHENOLS AGAINST TOBACCO SPECIFIC NITROSAMINE-INDUCED DNA DAMAGE IN NORMAL LUNG EPITHELIAL CELLS IN VITRO
(2017-03-24)The protective effect of polyphenol-rich haskap berry extracts against tobacco-specific nitrosamine ketone (NNK)-induced DNA damage was studied in vitro. Normal lung epithelial BEAS-2B cells were exposed to NNK, and to its ... -
DIETARY FLAVONOIDS REDUCE CARCINOGEN-INDUCED DNA DAMAGE IN BRONCHIAL EPITHELIAL CELLS IN VITRO
(2022-08-08)The potential of selected flavonoids in reducing carcinogen-induced reactive oxygen species (ROS) and DNA damage through the activation of nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2)/antioxidant response ... -
Dynamic Interplay Between Kaposi's Sarcoma-Associated Herpesvirus Latent Proteins in the Control of Oncogene-Induced Senescence
(2012-04-30)Acute oncogenic stress can activate autophagy and facilitate permanent arrest of the cell cycle through a failsafe mechanism known as oncogene-induced senescence (OIS). Kaposi's sarcoma-associated herpesvirus (KSHV) is the ... -
Evaluating the Role of the COP9 Signalosome and Neddylation during Cytokinesis and in Response to DNA Damage
(2021-01-07)The covalent attachment of the ubiquitin-like protein NEDD8 via lysine residues on target proteins, termed neddylation, regulates the activity and stability of numerous proteins, particularly through regulating the activity ... -
INVESTIGATING THE TUMOUR SUPPRESSING ROLE OF HACE1 AND ITS NOVEL CONTRIBUTION TO CARDIAC DEVELOPMENT USING THE ZEBRAFISH MODEL
(2017-10-12)HACE1 is an E3 ubiquitin-ligase that is epigenetically downregulated in various malignancies. The mechanisms underlying its role in tumourigenesis and in normal vertebrate development have not been well elucidated. We ... -
The Role of Nuclear Architecture in DNA Repair
(2018-09-28)Precise replication of genetic material and the maintenance of genome integrity by DNA repair mechanisms are critical processes in all organisms. The inaccurate repair or accumulation of unrepaired errors can overwhelm the ...